Preimplantation Genetic Testing (PGT) is an advanced technique performed as part of an IVF cycle that allows embryos to be screened for chromosomal abnormalities or specific inherited genetic conditions before they are transferred to the uterus. By identifying the healthiest, chromosomally normal embryos for transfer, PGT significantly improves the chance of a successful pregnancy and a healthy baby.
There are two main types: PGT-A (Preimplantation Genetic Testing for Aneuploidy), which screens all embryo chromosomes to identify those with the correct number, and PGT-M (Preimplantation Genetic Testing for Monogenic disorders), which tests for a specific single-gene condition known to be carried by one or both parents — such as cystic fibrosis, sickle cell anaemia, BRCA mutations, Huntington’s disease, or spinal muscular atrophy.
PGT is performed on a small biopsy taken from the embryo at the blastocyst stage (Day 5 or 6). The biopsied embryos are vitrified while results are analysed by our specialist genetics laboratory, and then transferred in a subsequent frozen embryo transfer (FET) cycle once results are confirmed. Only embryos that are unaffected by the tested condition are eligible for transfer.
Our PGT programme combines world-class genetics expertise with the full support of our IVF team, giving families at risk of inherited conditions the best possible chance of having a healthy baby.
Using next-generation sequencing (NGS) technology, we screen all 24 chromosomes of each embryo to identify those that are euploid (chromosomally normal). Transferring a euploid embryo reduces miscarriage rates and improves IVF success rates, particularly for women over 35 or those with recurrent implantation failure.
For couples who are carriers of a specific inherited genetic condition, PGT-M allows us to test each embryo for that exact mutation. Only unaffected embryos are transferred. This gives families a way to have a biological child without passing on a serious genetic condition, avoiding the difficult decisions that arise from prenatal diagnosis.
Our PGT programme is delivered in partnership with a fully accredited specialist genetics laboratory. Pre-test genetic counselling, embryo biopsy, genetic analysis, and results consultation are all coordinated by our team. The entire process — from initial genetics appointment to embryo transfer — is managed seamlessly across our centres.
PGT is integrated into an IVF cycle and follows a clear, step-by-step pathway. Here is how the process works from genetic consultation to embryo transfer.
Pre-test counselling, design of the genetic test probe (PGT-M), then a standard IVF cycle to create embryos.
Embryos biopsied at blastocyst stage; frozen while genetics lab analyses results (1–3 weeks for results).
Unaffected or euploid embryos are transferred in a frozen embryo transfer cycle; pregnancy test 14 days later.
Deciding to undergo PGT is often one of the most significant and emotionally complex decisions a family will make. Our genetics counsellors, fertility specialists, and nursing team provide unwavering support through every step of this journey.
Before any testing begins, you will meet with our specialist genetics counsellor, who will explain the testing process in full, discuss what the results may show, and help you think through how you will respond to every possible outcome — including the difficult possibility that no suitable embryos are found for transfer.
Our fertility specialists and geneticists collaborate on every PGT case. Results are interpreted by specialist clinical geneticists and reviewed by your fertility doctor before you receive them, ensuring you are given accurate, complete information with the clinical context you need to make an informed decision.
We coordinate every element of your PGT cycle — from the genetics referral and probe preparation for PGT-M, through the IVF stimulation and embryo biopsy, to the frozen embryo transfer cycle — with a clear written timeline so you always know exactly where you are in the process and what comes next.
PGT-A (Aneuploidy) screens every embryo's chromosomes to check that the right number of chromosomes is present (euploid). It does not test for specific inherited diseases. PGT-M (Monogenic) is a bespoke test designed in advance to look for a single specific gene mutation known to be carried by one or both parents. PGT-A can be added to any IVF cycle, while PGT-M requires a preparation period of several weeks before the IVF cycle begins to design and validate the individual test probe.
Embryo biopsy at the blastocyst stage is a well-established procedure with a very low risk of harm to the embryo. The biopsy removes just 5–7 cells from the outer layer of the blastocyst (the trophectoderm), which goes on to form the placenta rather than the baby itself. The inner cell mass, which becomes the foetus, is left completely intact. Studies consistently show that biopsied embryos have equivalent developmental potential and implantation rates compared to non-biopsied embryos of the same quality.
Schedule a consultation with our fertility experts and take the first step toward your parenthood journey.
Schedule a consultation with our fertility experts and take the first step toward your parenthood journey.
Schedule a consultation with our fertility experts and take the first step toward your parenthood journey.
Book your consultation with our fertility experts the first step toward your parenthood journey.
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